Recent advances in designing electroconductive biomaterials for cardiac tissue engineering
Ghovvati, M., Kharaziha, M., Ardehali, R. and Annabi, N., 2022. Recent advances in designing electroconductive biomaterials for cardiac tissue engineering. Advanced Healthcare Materials, p.2200055.
mplantable cardiac patches and injectable hydrogels are among the mostpromising therapies for cardiac tissue regeneration following myocardialinfarction. Incorporating electrical conductivity into these patches andhydrogels is found to be an efficient method to improve cardiac tissuefunction. Conductive nanomaterials such as carbon nanotube, grapheneoxide, gold nanorod, as well as conductive polymers such as polyaniline,polypyrrole, and poly(3,4-ethylenedioxythiophene):polystyrene sulfonate areappealing because they possess the electroconductive properties ofsemiconductors with ease of processing and have potential to restoreelectrical signaling propagation through the infarct area. Numerous studieshave utilized these materials for regeneration of biological tissues thatpossess electrical activities, such as cardiac tissue. In this review, recentstudies on the use of electroconductive materials for cardiac tissueengineering and their fabrication methods are summarized. Moreover, recentadvances in developing electroconductive materials for delivering therapeuticagents as one of emerging approaches for treating heart diseases andregenerating damaged cardiac tissues are highlighted