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- MSc, (2018- ): Fabrication and characterization of injectable nanocomposite hydrogel based on natural dentin-GelMA/bioactive glass for dental pulp regeneration
Annually, millions people in worldwide suffer from dental caries/decay of varying degrees, which can range from simple filling to more complex root canal treatments. Various factors such as tooth fractures(cracks), spreading inflammation and infection to the root canal followed by pulp inflammation as reversible pulpitis, irreversible pulpitis, tissue necrosis are exhibited that patients would require root canal therapy or pulp therapy such as direct pulp caping, pulpotomy, pulpectomy, etc. These methods have limitations and the most important complications of these methods are tooth discoloration and brittleness after pulp extraction. With the advancement of tissue engineering in the field of endodontics, effective steps have been suggested for more limited use of conventional treatments. In recent years, researchers have focused their research on a new solution, and it is the use of injectable nanocomposite hydrogels. Natural dentin is used in dental pulp engineering because of the variety of proteins and growth factors that affect the proliferation, growth, migration and differentiation of dental pulp cells, odontoblasts, and others. Also, due to their similarity with the growth factors of dentin and pulp extracellular matrix, it is very effective in dental pulp regeneration. Dentin in combination with hydrogels can provide unique properties such as angiogenesis and the formation of new blood vessels as a very important factor in dental pulp regeneration. Gelatin as a natural polymer has been suggested for dental pulp engineering because of its excellent properties such as water absorption, RGD sequence for greater cell adhesion, availability and affordability. One of the most important types of these hydrogels for dental pulp engineering is GelMA hydrogel. GelMA hydrogels are widely used in the pharmaceutical, food industries and tissue engineering. However, their inability to maintain post-injection strength has limited their use for pulp tissue engineering. In order to improve the properties of GelMA hydrogels, bioglass nanoparticles were incorporated into the hydrogel polymer networks. Bioglass nanomaterials have better cell adhesion due to their high surface area to volume ratio. Also bioglass nanoparticles have antimicrobial properties for application in dental pulp engineering. The purpose of the present study was to Fabrication and characterization of injectable nanocomposite hydrogel based on natural dentin-GelMA/bioactive glass for dental pulp regeneration.