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- MSc, (2018- ): Fabrication and characterization of electrolytic plasma oxidation and polyglycerol Sebacate composite coatings containing nitric oxide and copper nanoparticles on magnesium for cardiovascular applications
Nowadays, an increase in the risk of cardiovascular disease has significantly increased mortality in human societies. Coronary artery disease is the main cause of mortality amongst cardiovascular diseases. In this regard, the use of cardiovascular stents for the treatment of these diseases is increasing. Recently, use of metallic and polymeric degradable stents has increased due to the limitations of non-degradable stents. Magnesium is one of the degradable metals which recently proposed for use in cardiovascular stents. Magnesium is capable of opening and closing with vessels due to its high yield strength and good flexibility. One of the problems of using metals such as magnesium and its alloys is its high corrosion rate, which effects mechanical stability and the immune system activity. Surface and coating processes can be used to control corrosion of these materials. Recently, Conversion processes such as electrolytic plasma oxidation have been widely used to control magnesium corrosion rates. However, the presence of intrinsic porosities created during the process may not be desirable to control the corrosion rate of magnesium and its alloys. In this regard, the use of polymeric materials on the surface of the oxide layer to fill its pores is recognized as the best solution. Recently, polyglycerol Sebacate has been suggested for its biocompatibility, blood compatibility and suitable mechanical properties for tissue growth and proliferation in cardiovascular applications. Despite positive properties of polyglycerol Sebacate, it is not possible to accelerate process of vascular remodeling and angiogenesis without the use of appropriate growth factors and drugs. The use of appropriate factors and drugs such as nitric oxide accelerates growth of endothelial cells, inhibits the growth of smooth muscle cells and blood clotting. In addition, nitric oxide also has antibacterial properties. Accelerating the nitric oxide production process can also improve the physiological performance of this compound. One of the methods to control and accelerate the release of nitric oxide is the use of metallic catalysts such as copper along with nitric oxide compounds. The results of various studies on copper show that in addition to its catalytic and antibacterial properties, this metal can also contribute to vascularization. Accordingly, the development of polyglycerol Sebacate in nanocomposite coatings with targeted release of nitric oxide and copper nanoparticles on the surface of the oxide layer formed under the electrolytic plasma oxidation process could be useful for simultaneously controlling magnesium corrosion rate and accelerating vascular remodeling.