2018-Moazami.S.

Grade:

Graduated

Shima Moazami

MSc, (2018- ): Synthesize and characterization of nanocomposite bone adhesive based on polydopamine-co-acrylate-bredigite\starch for sternal closure

Abstract:

Cardiovascular disease and penetrating trauma, as one of the most common and progressive diseases in the modern era, has led physicians and surgeons to use various surgical techniques to help the patient recover. Middle sternotomy is one of the most standard and common methods to access organs within the chest. The sternum bone after the sternotomy must be fixed in the correct manner to heal at a later stage. Due to the structural features of the sternum bone and being active in hematopoiesis as well as the mobility of the chest as a result of breathing, its fixation after surgery is subject to certain conditions and criteria. In recent decades, various devices have been used to stabilize the sternum, each with its own advantages and limitations. The most notable of these are stainless steel wires with limitations. With the development of biomaterials, bone cements were introduced to stabilize the sternum but interfere with sternum healing. A new approach was introduced with the introduction of bone waxes, but they were still not suitable for sternum fixation. For these reasons, the researchers focused on a new solution called bone adhesives. One of the most important types of adhesives for sternum fixation is biomimetic adhesives with tight bonding in humid environments. These adhesives provide healing to the sternum with excellent bonding strength in the damp environment of the body as well as proper degradation rate. Acrylates are a class of synthetic polymers with a wide range of applications, with the ability to be hydrophilic and non-soluble in water due to crosslinking, but in order to overcome the limitations of this polymer due to the toxicity of vinyl monomers and crosslinking agents and modification for applications. Polydopamine, nanoparticles and starch will be used. The polydopamine-co-acrylate adhesive acts as a natural adhesive protein analog in humid environment. Bredigite nanoparticles induce bioactivity to the adhesive by releasing calcium, magnesium and silicon ions. Pre-gelatinized starch with fast and high water absorption is used to remove the poor homostatic properties of this adhesive. The proposed biomimetic adhesive has the potential to stabilize the sternum bone after the middle sternotomy.

Outcome: